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Parker Cancer ends here
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Discoveries

Where Break­throughs Begin

Parker Institute is a unified force of the world’s top immunotherapy researchers, working in tandem towards a common goal: curing cancer. Parker’s long-term funding relationships free scientists to do their work without interruption, so they can focus on fulfilling cancer immunotherapy’s promise. This expedites cutting-edge science without compromising scientific rigor — and gets life-saving treatments on a faster path to patients.

Scientist working in a lab surrounded by equipment

Research,
Rewired

Parker Institute partners with top academic centers to support leading-edge research, including the long-shot ideas most funders shy away from. We back projects that aim to unlock new, patient-ready cancer immunotherapy treatments for more types of cancer. In other words: therapies that can help more people, more quickly.

Research
Highlights

  • Neoantigen-Driven Targeting

    Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering

    March 19, 2026

    Xiaojing Chen, Zhiyuan Mao, E Motunrayo Kolawole, Margherita Persechino, Kevin M Jude, Masato Ogishi, Kelvin C Mo, Jami McLaughlin, Donghui Cheng, Xinyu Xiang, Xinbo Yan, Caitlin Gee, Shiqin Liu, Aerin Yang, Matthias Obenaus, Nan Wang, Miyako Noguchi, Tanya Stoyanova, John K Lee, Zinaida Good, Naomi R Latorraca , Brian D Evavold, Owen N Witte, K Christopher Garcia

    Stanford Medicine, University of California, Los Angeles

  • In Vivo Immune Engineering

    In vivo site-specific engineering to reprogram T cells

    March 18, 2026

    William A Nyberg, Pierre-Louis Bernard, Wayne Ngo, Charlotte H Wang, Jonathan Ark, Allison Rothrock, Gina M Borgo, Gabriella R Kimmerly, Jae Hyung Jung, Vincent Allain, Jennifer R Hamilton, Alisha Baldwin, Robert Stickels, Sarah Wyman, Safwaan H Khan, Shanshan Lang, Donna Marsh, Niran Almudhfar, Catherine Novick, Yasaman Mortazavi, Shimin Zhang, Mahmoud M AbdElwakil, Luis R Sandoval, Sidney Hwang, Simon N Chu, Hyuncheol Jung, Chang Liu, Devesh Sharma, Travis McCreary, Zhongmei Li, Ansuman T Satpathy, Julia Carnevale, Rachel L Rutishauser, M Kyle Cromer, Kole T Roybal, Stacie E Dodgson, Jennifer A Doudna, Aravind Asokan, Justin Eyquem

    University of California, San Francisco, Gladstone Institutes

  • Neoadjuvant PD-1 blockade in surgically resectable desmoplastic melanoma: cohort A of the phase 2 SWOG S1512 trial

    January 29, 2026

    Kari L Kendra, Shay L Bellasea, Zeynep Eroglu, Siwen Hu-Lieskovan, Katie M Campbell, William E Carson 3rd, David A Wada, Jose A Plaza, Gino K In, Alexandra Ikeguchi, John Hyngstrom, Andrew S Brohl, Bartosz Chmielowski, Nikhil I Khushalani, Joseph Markowitz, Marcus Monroe, Carlo M Contreras, Tawnya Bowles, Kurt Norman, Egmidio Medina, Cynthia R Gonzalez, Ignacio Baselga-Carretero, Ivan Perez Garcilazo, Agustin Vega-Crespo, Jia Ming Chen, Nataly Naser Al Deen, Sapna P Patel, Kenneth F Grossmann, Vernon K Sondak, Elad Sharon, James Moon, Michael C Wu, Antoni Ribas

    Dana-Farber Cancer Institute, University of California, Los Angeles, University of Southern California, University of Texas, MD Anderson Cancer Center

Scientist looking through a microscope

Why Immunotherapy?

Immunotherapy is changing what's possible in cancer treatment — harnessing the body's own defenses to fight disease in ways traditional therapies never could. A decade in, the breakthroughs are just beginning.

Learn more about Immunotherapy

Our Focus Areas

Our President of Research, Ira Mellman, is a pioneering force in cancer immunology. His decades of experience in top labs taught him what researchers need, and what they don’t. That’s why our science team doesn’t believe in prescriptive roadmaps. Instead, we define the frontiers and breakthroughs with the most potential and create the conditions for researchers to explore them freely. In 2026, we recalibrated our scientific priorities based on a decade’s worth of progress — and what we now see as the most promising pathways to a world without cancer.

Next-Gen Cell Therapies: Taking on Solid Tumors

Cell therapy has transformed treatment for blood cancers. Solid tumors are a different challenge: harder to reach, and harder to target. We're committed to making cell therapy work for them too.

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In Vivo Engineering: Cell Therapy Without The Cells

What if you didn’t need to remove a patient’s cells to engineer them? In vivo engineering delivers genetic instructions directly into the body, reprogramming immune cells where they already are: no extraction, no cell manufacturing, no waiting.

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Neoantigen-Driven Targeting: Moving past CARs

Every cancer carries a unique set of mutations — and those mutations can become targets. At Parker Institute and beyond, investigators are working to develop engineered T cell therapies that teach the immune system to recognize and attack a tumor’s distinct genetic fingerprint.

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Cancer Vaccines: Teaching The Body To Remember

A therapeutic vaccine doesn’t prevent disease. It treats it. Built from a tumor’s own mutations, these cancer vaccines work inside the body to teach the immune system what to attack. After decades of dead ends, this game-changing approach is starting to offer a path to protection that lasts.

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Systems Immunology: Cracking the Tumor Microenvironment

Cell therapy has transformed treatment for blood cancers. Solid tumors are a different challenge: harder to reach, and harder to target. We're committed to making cell therapy work for them too.

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Parker Institute Centers

At Parker Institute, we’re rewiring how research is done. Academia has long been competitive, and protective of ideas. But when the goal is curing cancer, anything that slows progress doesn't make sense. We’ve built something different: a network of world-leading institutions that share, challenge, and build on each other's work. Because that’s how we end cancer.

The Dana-Farber Cancer Institute is home to leading investigators who have made key discoveries in the immune response to cancer. Parker scientists at Dana-Farber work collaboratively across our network to deepen understanding of the tumor immune microenvironment — uncovering novel therapeutic targets, developing next-generation cellular therapies, and advancing vaccines as a platform for combination therapies to translate discoveries into immunotherapies that improve patient outcomes.

Satellite Research Centers

In recent years, we’ve expanded our network to include additional scientists from several more leading institutions. Together, we’re pushing cancer immunotherapy research farther and faster. 

Partner With Us

We are looking for bold collaborators and brilliant research minds to join our network. Contact us to learn more.

Partner With Us

About Parker Institute

Learn about our vision, history, and leadership.

About us