Gladstone Institutes

The development and use of cutting-edge genomic technologies to probe and control the human immune system is at the center of the groundbreaking research at the Gladstone-UCSF Institute of Genomic Immunology. Researchers combine advanced genomic profiling and functional screening with spatial mapping of human tumors to define the genetic programs that can be manipulated to enhance immune cell therapies. Working with the PICI network, Gladstone investigators are generating comprehensive atlases of cancer immunity and designing next-generation immunotherapies for clinical testing.

PICI at Gladstone Institutes is harnessing the power of genomics and CRISPR technologies to program the human immune system to treat cancer.

Areas of scientific interest:

• Multimodal genomic profiling of patient immune cells
• Spatial mapping of the tumor immune compartment
• Systematic functional genetic screening in human immune cells
• Synthetic programming of cellular immunotherapies

Alexander Marson, MD, PhD | Director