Roberta Zappasodi, PhD

Zappasodi is investigating how co-stimulation, with agonist anti-GITR, and checkpoint blockade, with antagonist anti-CTLA4 monoclonal antibodies affect suppressive T-cells in tumor microenvironment. In particular, she is involved in the study of the mechanisms of action responsible for the success or failure of these antibodies in preclinical mouse models. In addition, Zappasodi is also investigating the induction of immune responses to self-antigens using a vaccine based on Alphavirus-like replicon particles (VRP) alone or in combination with immune modulation.