Jimmie Ye, PhD

Jimmie Ye, PhD, received his bachelor’s degrees in Electrical Engineering and Computer Sciences and Bioengineering from UC Berkeley and a PhD in Systems Biology from UC San Diego.

After a postdoctoral fellowship at the Broad Institute with Aviv Regev, PhD, Dr. Ye started his lab at UCSF five years ago. At UCSF, he is an Associate Professor in the Department of Medicine and is a member of the Institute for Human Genetics, the Bakar Institute for Computational Health Sciences and the Gladstone Institute for Genomic Immunology. He is also an affiliated investigator at PICI and the Chan Zuckerberg Biohub.

The Ye lab is interested in understanding how genetic variants influence the transcriptional response of immune cells to their environment. The lab develops experimental and computational methods for the high-throughput single-cell measurement and analysis of gene expression across population cohorts, perturbational screens and tissue regions. These approaches are being used to study primary human immune cells in both healthy donors and disease patients to dissect gene regulatory mechanisms that underlie host pathogen interactions, the development of autoimmunity, and natural and acquired cancer immunity.