Skip to content
Parker Institute for Cancer Immunotherapy
Search Close

Darwin Ye

Parker Scholar

Early Career Researcher


Darwin Ye is a Parker Scholar and PhD candidate in Cancer Biology training in the laboratory of Andy Minn, MD, PhD, at the University of Pennsylvania School of Medicine. Ye has developed expertise combining mouse modeling with state-of-the-art technologies in lineage tracing and single-cell sequencing to understand:

  1. What drives cancer cells to become resistant to immune checkpoint blockade therapies
  2. How tumors can be therapeutically targeted to either prevent or disrupt the process by which cancer cells evolve to become resistant

Ye’s current research focuses on modeling a clinical trial of immune checkpoint blockade in lung cancer patients at Penn Medicine’s Abramson Cancer Center in order to effectively redesign future clinical trials utilizing the mechanistic insights that Ye acquires from mice. He hopes to build a comprehensive mouse modeling toolkit to accelerate high-impact discoveries in the cancer immunotherapy space.

Education & Training

  • 2017-present: PhD (Cancer Biology) Candidate, University of Pennsylvania
  • 2014-17: Research Student, Dana-Farber Cancer Institute
  • 2014: Research Intern, Merck

Awards & Honors

  • 2022: Parker Scholar