Matthew Gubin, PhD Parker Bridge Fellow Biography Matthew Gubin, PhD, is a Parker Bridge Fellow and Assistant Professor in the Department of Immunology at the University of Texas MD Anderson Cancer Center. Gubin received his BS degree in Biology and his PhD in Immunology from the University of Missouri. Gubin then completed his postdoctoral work in Dr. Robert Schreiber’s lab at Washington University as Cancer Research Institute Irvington fellow. During his postdoc, his research focused on the use of immunogenomics to uncover the antigenic targets of T cells during cancer immunotherapy. Gubin and colleagues demonstrated in preclinical models that tumor-specific mutant antigens (neoantigens) could be rapidly identified and used as effective personalized neoantigen cancer vaccines in mice when given either alone or in combination with other immunotherapies. Gubin then joined the faculty as an Instructor at Washington University, continuing his work in Dr. Schreiber’s lab, where he focused on the use of high dimensional analyses approaches to better understand effective cancer immunotherapy. By leveraging single cell RNA sequencing and mass cytometry by CyTOF, he and his colleagues identified dynamic remodeling of not only the intratumoral immune cell lymphoid compartment but also the myeloid compartment by immune checkpoint therapy, including shared and distinct changes occurring that was dependent upon which immune checkpoint therapy was used. Gubin recently started independent research at MD Anderson where his lab is focused on (1) developing metastatic cancer models expressing authentic (versus model) tumor-specific neoantigens, (2) high dimensional analyses of primary and metastatic tumors in both animal models and human patients, and (3) developing effective combinatorial therapies targeting neoantigens in both primary and metastatic cancer. Education & Training 2008: Missouri Health Science Research Day Award 2009: Chancellor's Award for Public Outreach 2010: Professional Presentation Travel Fellowship 2010: Missouri Superior Graduate Student Award 2010: Life Science Week Research Competition Honorable Mention 2011: Invitation to the NIH National Graduate Student Research Conference 2011: Clinical and Translational Research and Education Abstract Award 2011: Institute for Clinical and Translational Science Travel Award 2016: Invitation to the 3rd Annual Symposium on the Future of Cancer Science at The University of Texas MD Anderson Cancer Center 2014: Cancer Research Institute Postdoctoral Fellowship 2019: Cancer Prevention and Research Institute of Texas (CPRIT) Scholar in Cancer Research 2019: The University of Texas Rising STARs Award 2019: The University of Texas MD Anderson Cancer Center Support Grant (CCSG) New Faculty Award Awards & Honors 2004: University of Missouri, Columbia, MO, B.S., Biology 2012: University of Missouri, Columbia, MO, Ph.D., Immunology 2017: Washington University School of Medicine, St. Louis, MO, Postdoctoral Fellowship, Cancer Immunology