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Diane Da Silva, PhD, MS

Associate Director, Translational Medicine

Translational and Regulatory


Diane Da Silva, PhD, MS, is the Associate Director of Translational Medicine at PICI. She directs the execution of the PICI translational suite of biomarker assays and contributes to disease- and immune-specific biomarker approaches in collaboration with PICI’s clinical and informatics teams.

Prior to joining PICI, Dr. Da Silva was research faculty in the Division of Gynecologic Oncology, Obstetrics and Gynecology Department at the Keck School of Medicine of USC where she oversaw the collection of a large clinically annotated biorepository of gynecologic cancer specimens for translational research. Dr. Da Silva also served as the scientific director of the Beckman Center for Immune Monitoring at the USC Norris Comprehensive Cancer Center. Dr. Da Silva’s research involved applying immune modulation strategies to enhance natural and therapeutic vaccine-induced immunity against gynecologic cancers and identifying clinically relevant molecular and cellular biomarker signatures in human clinical trial biospecimens that are predictive of response to immunotherapy. Dr. Da Silva has co-authored over 60 peer-reviewed scientific journal articles, review articles, and book chapters.

Dr. Da Silva received her Ph.D. in Cancer Immunology and Immunotherapy from Loyola University Chicago. She completed her NCI postdoctoral training fellowship at the University of Southern California focused on identifying mechanisms of viral and tumor immune evasion. She later obtained an M.S. degree in Regulatory Science from the USC School of Pharmacy with an emphasis on clinical trial research.