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LOS ANGELES — Internet billionaire Sean Parker has spent hundreds of millions of dollars of his fortune — and almost entirely his fortune alone — in an effort to build a new model for developing treatments that harness the immune system to fight cancer.

Now, his Parker Institute for Cancer Immunotherapy is increasingly looking to sources of funding beyond Parker himself.

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More than three years after its launch, PICI, as the nonprofit is sometimes known, has been approached by two major donors who have expressed interest in funding one of its seven centers at leading academic medical institutions, Parker told STAT. (Parker declined to say who, saying he’d “have a lot of pissed-off people” if he disclosed their names.) The institute expects to announce their names within the next year.

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