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Gut Bacteria Modulates Response to Immunotherapy in Melanoma

Bacteria that live in the human digestive tract can influence how cancer responds to immunotherapy, opening a new avenue for research to improve treatment, according to a team led by researchers at The University of Texas MD Anderson Cancer Center, Houston (Science 2017; doi:10.1126/science.aan4236).

Wargo and colleagues are working with the Parker Institute for Cancer Immunotherapy, San Francisco, to develop a clinical trial that combines checkpoint blockade with microbiome modulation.

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